![]() ![]() Other reported treatment alternatives include intraoperative radiation therapy, stereotactic radiation therapy (SRT), or surgical limb-sparing using an allograft. Furthermore, amputation can also lead to some negative sequelae: metastasis, oedema, dehiscence of the wound or arthrosis of the ipsilateral limb and pneumonia. However, this option is not optimal since the dog’s gait is subsequently impacted and some dogs are not good candidates for amputation due to concomitant orthopedic diseases or neurologic conditions. Currently, amputation of the affected limb is the most recommended therapeutic and palliative treatment option. The most affected anatomic site is the proximal humerus. The dog’s age also impacts the prevalence of this disease, with older dogs facing a higher probability of developing osteosarcoma. Osteosarcoma is the most common bone tumor in dogs, especially large breed animals (Doberman, Golden retriever, Rottweiler). This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: VB received the fundings Axelys (formerly Aligo) The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. Received: AugAccepted: JanuPublished: January 24, 2022Ĭopyright: © 2022 Le Bras et al. PLoS ONE 17(1):Įditor: Julia Molnar, New York Institute of Technology, UNITED STATES (2022) Personalized endoprostheses for the proximal humerus and scapulohumeral joint in dogs: Biomechanical study of the muscles’ contributions during locomotion. The identification of the most important muscles and their impact on the kinematics of the prosthetic joint lead to an improvement of the endoprosthesis design relevance and implantation feasibility.Ĭitation: Le Bras L-A, Timercan A, Llido M, Petit Y, Seguin B, Lussier B, et al. A quasi-static study based on an optimization method, the minimization of the sum of maximal muscle stresses, was carried out to assess the contribution of each muscle to the shoulder function. For each of the endoprosthesis designs, a minimal number of muscles needed to ensure stability and a certain degree of joint movement during walking is sought. This study focuses on the biomechanical effects of endoprostheses and shoulder muscle kinematics. Prototypes of both articulated and monobloc (no mobility) patient-specific endoprostheses have been designed to spare the limb afflicted with osteosarcoma of the proximal humerus. Until recently, amputation or limb-sparing surgery leading to an arthrodesis coupled with chemotherapy were the only available treatments, but they often lead to complications, reduced mobility and highly impact dog’s quality of life. It commonly occurs in the proximal humerus, the most affected anatomic site. Osteosarcoma represents one of the most common bone tumours in dogs. ![]()
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